暴磊
发布时间:2023-09-16 浏览次数:0次
暴磊,博士,副教授,硕士研究生导师,劳动卫生与环境卫生学教研室主任。主要研究方向为纳米材料与环境污染物健康效应。主持国家自然科学基金青年科学基金项目1项,省部级项目4项,参与国家自然基金重大研究计划重点项目1项。以第一作者在国内外权威期刊发表论文5篇。
承担课题
1. 国家自然基金青年基金:基于TCR免疫组库研究蛋白冠启动适应性免疫在纳米二氧化硅致肺纤维化中的作用与机制(82204074),主持人,2023.01-2025.12
2. 河北省高等学校青年拔尖人才项目:SCFAs调控内质网应激介导的糖原自噬在SiNPs致肺纤维化的机制研究(BJK2023006),主持人,2023.01-2025.12
3. 河北省重点研发计划卫生健康专项:基于Smek/HDACs/组蛋白乳酸化途径对短链脂肪干预尘肺病进程的作用与机制研究(22377735D),主持人,2022.07-2025.06
4. 河北省自然科学基金青年基金项目:矽肺TCRα CDR3免疫组库特征及基于优势CDR3序列的T细胞所识别的矽肺相关抗原研究(H2020206139),主持人,2020.01-2022.12
5. 河北省高等学校科学研究青年基金:基于TCRα CDR3免疫组库的免疫毒性评价效应及生物标志价值研究(QN2020175,3万),主持人,2020.01-2022.12
6. 8181801威尼斯登录“春雨计划”优秀青年基金:工程化外泌体通过铁死亡途径缓解PM2.5导致的上皮细胞间质化的作用及机制研究,30万,主持人,2023.01-2025.12
7. 8181801威尼斯登录 “导师制-青年科技创新人才托举培育计划”: TCR在纳米SiO2颗粒致肺纤维化中抗原识别作用和机制研究,10万,主持人,2021.01-2022.12
代表性论文
1. Bao L, Geng Z, Wang J, He L, Kang A, Song J, Huang X, Zhang Y, Liu Q, Jiang T, Pang Y, Niu Y, Zhang R. Attenuated T cell activation and rearrangement of T cell receptor β repertoire in silica nanoparticle-induced pulmonary fibrosis of mice. Environ Res. 2022; 213:113678.
2. Bao L, Hao C, Wang J, Guo F, Geng Z, Wang D, Zhao Y, Li Y, Yao W. In vitro co-culture model of human monocyte-derived dendritic cells and T cells to evaluate the sensitization of dinitrochlorobenzene. Ecotoxicol Environ Saf. 2021 May 18; 220:112331.
3. Bao L, Hao C, Wang J, Wang D, Zhao Y, Li Y, Yao W. High-Dose Cyclophosphamide Administration Orchestrates Phenotypic and Functional Alterations of Immature Dendritic Cells and Regulates Th Cell Polarization. Front Pharmacol. 2020 May 25; 11:775.
4. Bao L, Hao C, Liu S, et al. Dendritic cells trigger imbalance of Th1/Th2 cells in silica dust exposure rat model via MHC-II, CD80, CD86 and IL-12. RSC Advances, 2018, 8(46):26108-26115.
5. Qu Y, Bao L, Zhao Y, Li Y, Ding M, Hao C, Yao W. Dendritic cells activated by cimetidine induce Th1/Th17 polarization in vitro and in vivo. Toxicol In Vitro. 2022 Sep;83:105395.
6. Zhao Y, Hao C, Bao L, et al. Silica particles disorganize the polarization of pulmonary macrophages in mice. Ecotoxicol Environ Saf. 2020; 193:110364.
7. Yao W, Ding M, Bao L, Zhao Y, Wang D, Li Y, Qu Y, Hao C. Human monocyte-derived dendritic cells as an in vitro alternative model cell to evaluate the immunotoxicity of 2, 4-Dinitrochlorobenzene. Toxicol Lett. 2020 May 13;330:118-127.
8. Liu S, Hao C, Bao L, Zhao D, Zhang H, Hou J, Wang D, Chen H, Feng F, Yao W. Silica Particles Mediate Phenotypic and Functional Alteration of Dendritic Cells and Induce Th2 Cell Polarization. Front Immunol. 2019 Apr 24; 10:787.
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